Figure 2

Distributions of the values of the pairwise coupling energies for all possible pairs of positions in sequences with different native states on 2D and 3D lattices. The values of the coupling energies for all possible pairs of positions in 10 sequences of 16 residues with different native states on a 2D lattice with full enumeration (a) and 10 sequences of 27 residues with different native states on a 3 × 3 × 3 3D lattice (b) were calculated. The distributions of the values of the pairwise coupling energies for positions in contact and not in contact in these native conformations are shown by filled and empty bars, respectively.