Figure 1

Distribution of Z scores for 473 cases in the long list using the following three perturbation-based scores. (a) : the percentage of highly conserved (Z ≤ -2) and moderately conserved (-2<Z ≤ -1) cases is 47% and 20%; (b) δf _i : the percentage of highly conserved and moderately conserved cases is 48% and 20%; (c) δλ_{m, i}: the percentage of highly conserved and moderately conserved cases is 41% and 26%.