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Table 2 Overview of all known structures of β-propellers containing Asp-box or s-Asp-box motifs

From: Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase families

Family

Protein

Species

# Blades

# Asp- boxes

Blades with Asp-box

# short- Asp- boxes

Blades with short-Asp-box

# pdb files

Highest resolution pdb file

GH33

Sialidase NanI

Clostridium perfringens

6

4

1, 2, 3, 4

0

-

4

2bf6 (0.97 A)

 

Sialidase

Micromonospora viridifaciens

6

5

1, 2, 3, 4, 5

0

-

10

1w8o (1.70 A)

 

Sialidase

Salmonella typhimurium

6

3

1, 2, 4

1

3

5

3sil (1.05 A)

 

Sialidase NanA

Streptococcus pneumoniae Hungary19A-6

6

4

1, 2, 3, 4

0

-

1

2vvz (2.50 A)

 

Sialidase NanB

Streptococcus pneumoniae TIGR4

6

4

1, 2, 3, 4

0

-

3

2vw2 (1.70 A)

 

Sialidase

Vibrio cholera

6

4

1, 3, 4, 5

0

-

3

1w0p (1.60 A)

 

Cytoplasmic sialidase Neu2

Homo sapiens*

6

3

2, 3, 4

0

-

14

1so7 (1.49 A)

 

Intramolecular trans-Sialidase

Macrobdella decora*

6

4

1, 2, 3, 4

0

-

5

2sli (1.80 A)

 

Trans-sialidase

Trypanosoma cruzi*

6

3

1, 3, 4

0

-

13

1ms9 (1.58 A)

 

Sialidase

Trypanosoma rangeli*

6

3

1, 3, 4

0

-

9

1n1t (1.60 A)

 

Pseudaminidase

Pseudomonase aeruginoasa

6

3

2, 3, 4

0

-

1

2w38 (1.90 A)

GH58

Endosialidase

Bacteriophage K1F †

6

2

1, 4

0

-

2

1v0e (1.90 A)

GH74

Xyloglucanase

Clostridium thermocellum

7 + 7

4 + 5

2, 3, 4, 6/2, 3, 4, 5, 6

0

-

2

2cn3 (1.95 A)

 

Cellobiohydrolase

Geotrichum sp. M128*

7 + 7

4 + 5

2, 3, 4, 6/2, 3, 4, 5, 6

0

-

2

1sqj (2.20 A)

Not known

YP_299179.1

Ralstonia eutropha

7

5

2, 3, 4,

0

-

1

3b7f (2.20 A)

Vps10 domain

Sortilin

Homo sapiens*

10

9

1, 2, 3, 4, 5, 6, 7, 8, 9

0

-

1

3f6k (2.00 A)

GH32

Exo-inulinase

Aspergillus niger*

5

1

2

2

1, 3

3

1y4w (1.55 A)

 

Invertase

Thermotoga maritima

5

0

-

3

1, 2, 3

2

1w2t (1.87 A)

 

Cell-wall invertase

Arabidopsis thaliana*

5

0

-

2

1, 3

5

2ac1 (2.15 A)

 

Fructosidase

Cichorium intybus

5

0

-

2

1, 3

5

1st8 (2.35 A)

GH43

Xylosidase

Bacillus halodurans

5

0

-

1

1

1

1yrz (2.00 A)

 

Xylosidase

Bacillus subtilis

5

0

-

1

1

1

1yif (1.80 A)

 

Arabinase

Bacillus subtilis

5

0

-

1

1

1

1uv4 (1.50 A)

 

Arabinase

Cellvibrio japonicus

5

0

-

1

1

3

1gyh (1.89 A)

 

Xylosidase

Clostridium acetobutylicum

5

0

-

1

1

2

1y7b (1.60 A)

 

Xylosidase

Geobacillus stearothermophilus

5

0

-

1

1

4

2exh (1.88 A)

 

Arabinase

Geobacillus thermodenitrificans

5

0

-

1

1

1

1wl7 (1.90 A)

 

Xylosidase/ara- binofuranosidase

Selenomonas ruminantium

5

0

-

1

1

1

3c2u (1.30 A)

  1. There are currently 76 known structures with Asp-box β-propeller domains. These have 2–9 Asp-boxes and represent 16 different proteins and 5 different protein families. There are furthermore 29 known structures with 1–3 s-Asp-box motifs, which represent 12 different proteins and 2 families of 5-bladed β-propellers. Most known structures are from bacteria (unmarked), but there are also several from eukaryotes (species marked by *) and one from a bacteriophage (marked by †).
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BMC Structural Biology

ISSN: 1472-6807

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