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Table 4 RQA analysis of different wild type (wt) or mutant FP and CT peptide couples

From: A computational approach identifies two regions of Hepatitis C Virus E1 protein as interacting domains involved in viral fusion process

Sequence type

FP

CT

REC

DET

LAM

   wild type

wt

wt

13.00

26.32

24.81

   FP mutant

Y276R

wt

12.90

26.50

25.00

   FP mutant

Y276A

wt

13.50

27.50

23.80

   FP mutant

Y276F

wt

13.10

27.60

26.60

   FP mutant

G282D

wt

12.89

29.50

25.00

   FP mutant

F285A

wt

13.10

27.15

25.20

   CT mutant

wt

V333A

11.72

10.83

13.33

   CT mutant

wt

L337A

11.52

10.17

10.17

   CT mutant

wt

M347A

12.01

13.82

21.13

   CT mutant

wt

L356W

11.72

16.67

21.67

   CT mutant

wt

A360W

11.84

15.26

20.81

   double mutant

F285A

V333A

12.60

17.82

12.40

   double mutant

Y276R

L337A

11.40

11.97

10.26

   double mutant

Y276A

M347A

12.70

17.70

20.00

  1. *: the amino acid change of mutated versions is reported