TY - JOUR AU - Hu, Jing AU - Yan, Changhui PY - 2009 DA - 2009/08/03 TI - A tool for calculating binding-site residues on proteins from PDB structures JO - BMC Structural Biology SP - 52 VL - 9 IS - 1 AB - In the research on protein functional sites, researchers often need to identify binding-site residues on a protein. A commonly used strategy is to find a complex structure from the Protein Data Bank (PDB) that consists of the protein of interest and its interacting partner(s) and calculate binding-site residues based on the complex structure. However, since a protein may participate in multiple interactions, the binding-site residues calculated based on one complex structure usually do not reveal all binding sites on a protein. Thus, this requires researchers to find all PDB complexes that contain the protein of interest and combine the binding-site information gleaned from them. This process is very time-consuming. Especially, combing binding-site information obtained from different PDB structures requires tedious work to align protein sequences. The process becomes overwhelmingly difficult when researchers have a large set of proteins to analyze, which is usually the case in practice. SN - 1472-6807 UR - https://doi.org/10.1186/1472-6807-9-52 DO - 10.1186/1472-6807-9-52 ID - Hu2009 ER -