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Table 2 Comparison of the 66.3 kDa protein with Ntn hydrolases of known structure (DALI).

From: Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography

protein

Abbreviation

PDB-ID*

Z-score

rmsd

[Ã…]

Lali

Nres

% ID

cephalosporin acylase

CA

1oqz

17.0

3.6

360

684

11

penicillin V acylase

PVA

3pva

16.2

3.0

222

334

6

conjugated bile acid (= choloylglycine) hydrolase

CBAH

2bjf

16.2

3.1

224

328

6

penicillin G acylase

PGA

1k5s

15.4

3.4

244

557

11

IMP cyclohydrolase

IMPC

2ntm

8.4

3.2

165

202

14

20 S proteasome

-

1ryp

8.3

3.1

161

205

7

  1. Only hits with a Z-score ≥ 7 and with an assigned cellular function are listed here. A complete list of all revealed similar structures can be found in Additional file 4: Table S1. Extended list of structures with a similar fold as the 66.3 kDa protein revealed using the program DALI.
  2. * For redundant protein, the PDB-ID and the corresponding values are given only for the best hit. Z-score = value for comparison. Hits with Z-scores ≤ 2 are spurious. rmsd = root mean square deviation between the aligned residues, Lali: number of structurally equivalent residues, Nres: number of amino acids in the protein, % ID: percentage of identical amino acids over all structurally equivalent residues.