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Figure 8 | BMC Structural Biology

Figure 8

From: Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations

Figure 8

Possible origins of mutational effects of L579F, L624P, and H606Q derived from the snapshots of various mutant simulations at 44 ns. The JH2 C-helix is shown in orange, the β-4 sheet in blue, and the β-5 sheet in red. In L579F, F579 interacts with nearby F628, changes the surrounding packing pattern, and causes conformational changes between the β-4 and β-5 sheets. In L624P, P624 enforces a conformational change of the β-5 sheet. In H606Q, the interactions between the H606 side chain and the L604/L609 backbones are disrupted and the conformation of the loop (604 to 609) is changed.

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