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Table 1 Summary of predicted effects of JAK2 mutations.

From: Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations

Mutation Interactions JH1/JH2 interface Openness MPD implication[17, 34, 43, 44] Experimental evidence[41]
  I-1 I-2 I-3    
Wild-Type O O O O no benign
K539L XX XX X XX yes  
R564L X XX X XX yes  
L579F O X X X yes  
H587N X X X X yes  
S591L XX XX X XX yes  
14-del XX XX X XX yes  
K603QN667K O O O O no  
H606Q X XX X XX yes  
V617C O O O O   benign
V617F X XX X XX yes deleterious
V617I XX O O XX   deleterious
V617Y O X O X   
C618R XX XX X XX yes  
L624P X X O X yes  
  1. Summary of predicted effects of JAK2 mutations on I-1, I-2, and I-3 interactions and total effects on the JH1/JH2 interface; and the comparison with experimental/clinical evidence. "O" indicates benign; "X", mildly deleterious; "XX", severely deleterious. The "JH1/JH2 openness" is defined as severely deleterious when I-1 or I-2 is severely deleterious.