Skip to main content

Table 1 Representations, original features, and the new features.

From: Machine learning integration for predicting the effect of single amino acid substitutions on protein stability

Repr.

Original Feat.

New Repr.

New Feat.

SO

± 3 neighbors (± 3 NE)

Mutation (MUT)

T/pH

SO*

PAM 250 (PAM)

TO

Mutation (MUT)

C α contacts (CA)

SA/T/pH

TO*

PAM 250 (PAM)

C α B-factor (BFA)

C α B-factor (BFB)

C α and C β contacts (CB)

ST

± 3 neighbors (± 3 NE)

Mutation (MUT)

C α contacts (CA)

SA/T/pH

ST*

PAM 250 (PAM)

C α B-factor (BFA)

C α B-factor (BFB)

C α and C β contacts (CB)

  1. In all three representations, amino acid substitution likelihood is used as a feature. B-factors of the C α and C β atoms and spatial neighbor determined using both C α and C β atoms are features introduced into TO and ST. The abbreviations are given only for the features that we add.
Back to article page

BMC Structural Biology

ISSN: 1472-6807

Contact us