Figure 5
Interface signature motif. The signature motif for (a) CLASS V (m1vib, m1clo, m1pyo, and m1shi), and (b) CLASS VI (m1lac, m2lac, m3lac, and m1bfi); based on superposition of all the LuxS structures belonging to a particular class and prediction of structurally superposing residues (by manual inspection) as depicted pictorially to form a motif at Imin = 6%. The superposed backbone structures are represented as transparent new cartoon and the interface cluster residues forming the motif are shown as van der Waal's spheres, specific colour represents residues from a specific protein within the class. The different regions are marked and labelled with the corresponding residues in different colours; red/pink indicates completely/partially conserved residues respectively within the class, whereas violet indicates no conservation within the class. The completely/partially conserved residues are in bold/ bold italics respectively. The residues coming from only one subunit are underlined in blue (chain A) and mauve (chain B).