Molecular determinants of the binding of H3K4, H3K9 and H3K27. The peptides H3K4 (a.a. 1-7), H3K9 (a.a. 5–11), and H3K27 (a.a. 23–29) are oriented vertically and depicted in purple with the atomic details of the side chains. The interacting amino acids from the CDs of the NSD members are indicated in brown and numbered. Green dashed lines represent the hydrogen bonds. The hydrophobic interactions are omitted to declutter the figure. The schematic was generated with the program Ligplot.