Figure 6From: Structural importance of the C-terminal region in pig aldo-keto reductase family 1 member C1 and their effects on enzymatic activity The measurement of key distance for reduction reaction. A The crucial distance to initiate catalytic reaction and relative position of the catalytic tetrad and cofactor in the active site of C-type and T-type. The catalytic tetrad and 5α-DHT in C-type (blue) and T-type (pink) are displayed as stick models. The key distances are given in nm. B The distance between C3 of 5α-DHT and C4N of NADPH. C The distance between C3 of 5α-DHT and OH of Tyr55. The both distances in C- and T-types were measured during 20 ns simulation time. Blue and red lines indicate C-type and T-type, respectively.Back to article page