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Figure 2 | BMC Structural Biology

Figure 2

From: The observation of evolutionary interaction pattern pairs in membrane proteins

Figure 2

Examples of spatially interacting sub-sequences with respect to their corresponding pattern interaction network. A: More specifically, KI6 and AM7 representative patterns (right) interact with AL8 (left). All patterns have mutations. Mutational positions are marked with X. Possible amino acid replacements for AL8 representative (left) are coloured and arrows point to the respective X position. Black arrows point to the respective X position of the KI6 and AM7 representatives. With this interaction network we can track, which substitutions occur during the evolution, without influence on the interaction. B: The top and side view illustrations of Bacteriorhodopsin trimer (PDB-Id:1brr) are indicating where the interacting patterns are present in the helices of chain A. Generally, spheres illustrate residue-residue contacts. Red coloured spheres illustrate variable positions (X).

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