Classification result for major intrinsic protein (PF00230) representative unknown structures. 5,993 of 6,420 representative proteins have been correctly assigned to PF00230. The greater the evolutionary degree of freedom (x-axis), the more variability occurs within PF00230-EIPPs. This leads to more classified proteins. On the other side, EIPPs become more unspecific for a membrane protein family which leads to wrong classified. In this case, PF00230-EIPPs were covered in 14 PF01036-proteins.