Pairwise sequence alignment of OC43 3CLpro with the template structure of 3D23. Sequence alignment revealed a high identity of 82.3%. Asterisks indicate conserved residues between target and template. Conserved active site residues are highlighted in red. Important residues within the oxyanion loop (yellow), S1 pocket (blue) and S2 pocket (black) are also highlighted to display high degree of conservation within the active site.