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Figure 8 | BMC Structural Biology

Figure 8

From: Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies

Figure 8

Binding conformation of 16R within the active pocket of the 3CLpro. (a) Pose of 16R within the active site of the SARS-CoV 3CLpro. Hydrogen bonds (yellow dashes) are formed with Gly143, His163 and Glu166. (b) 16R assumes a similar pose when bound to the OC43 3CLpro. A notable difference is the loss a hydrogen bond with Glu166. Hydrogen bonds with Gly143 and His163 are however maintained.

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BMC Structural Biology

ISSN: 1472-6807

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