The TM7-binding mode. (Top left) Overview of receptor–ligand interactions. (Top right) Heatmap shows preferred peptide–receptor interactions (interatomic distance < 4 Å) within the high-scoring poses that adopt this binding mode. X: observed in the representative pose. (Bottom) A cross-eyed stereogram. Orange: hydrogen bond, red: salt bridge or charge-assisted hydrogen bond, blue: CH–O hydrogen bond, magenta: lone pair-π, black: hydrophobic.