Table 1 Comparison of motifs for DNA binding and catalysis
From: Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase
| Â | 1FLZ (EcUNG) | 1SSP (hUNG) | 4QCB (vUNG) |
|---|---|---|---|
Catalytic water-activating loop | 62-GQDPYH-67 | 143-GQDPYH-148 | 66-GIDPYP-71 |
Pro-rich loop | 84-AIPPS-88 | 165-PPPPS-169 | 84-FTKKS-88 |
Uracil specificity β-strand | 120-LLLN-123 | 201-LLLN-204 | 117-IPWN-120 |
Gly-Ser loop | 165-GS-166 | 246-GS-247 | 160-KT-161 |
Leu intercalation loop | 187-HPSPLSVYR-195 | 268-HPSPLSAHR-276 | 181-HPAARDR-187 |
Active site residues | D64, Y66, F77, N123, H187, L191 | D145, Y147, F158, N204, H268, L272 | D68, Y70, F79, N120, H181, R185 |