Fig. 3
From: Free fatty acid receptors: structural models and elucidation of ligand binding interactions
The ligand binding mode at the FFA1 crystal structure and homology models. a: the binding model of TAK-875, the ago-allosteric ligand in the FFA1 crystal structure, the ligand is pointed between helices 3 and 4 (mode 1 in the text). b: The binding mode of GW9508, the high potency agonist in the previous rhodopsin-based homology model of FFA1. The model was obtained from ref 12. c: The binding mode of TAK-875 in the PAR1-based model of FFA1. Hydrogen bonds are in black