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Fig. 5 | BMC Structural Biology

Fig. 5

From: A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

Fig. 5

Comparison of the mode of binding of E6a to that of other chemotherapeutic quinones. Residues from the hNQO1-E6a complex are shown in blue and E6a is shown in green. Residues from the quinone complex structures are shown in orange (ARH019), pink (E09), and brown (RH1). a, c and e depict the conformational changes in the active site residues while (b), (d) and (f) show variations of binding modes of E6a and quinone-based chemotherapeutic agents ARH019 (orange), E09 (pink) and RH1 (brown), respectively

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