Fig. 6
From: A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone
Comparison of E6a and coumarin-based NQO1 inhibitors binding to the active site of hNQO1. Residues from the hNQO1-E6a complex are shown in blue and E6a is shown in green. Residues from the coumarin complexes are shown in gray (dicoumarol) and brown (AS1). a and c show the structural differences in the active site residues of hNQO1-dicoumarol and hNQO1-AS1 with reference to the hNQO1-E6a complex. b and d show the differences in binding orientations of dicoumarol (gray) and AS1 (brown) compared to that of E6a