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Table 1 GAL4 cell assay selectivity profile for BIO399 toward RORα and RORβ in GAL4

From: Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

ROR γ α β
IC50 (uM) 0.043 (+/− 0.01uM; N = 6) >10 (N = 2) >1.2 (N = 2)
Selectivity (X) - >235 >28.2