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Table 1 GAL4 cell assay selectivity profile for BIO399 toward RORα and RORβ in GAL4

From: Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

ROR

γ

α

β

IC50 (uM)

0.043 (+/− 0.01uM; N = 6)

>10 (N = 2)

>1.2 (N = 2)

Selectivity (X)

-

>235

>28.2