Fig. 7From: Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3Results of 500 ns long rstr4 run. The expected ICL3 closure was observed under 100 ns, when an additional bond restraint was imposed between the backbone atoms in the ligand-binding site. a ICL3’s center of mass (x and y only) color-coded by time step. Lines represent the G protein’s a helix x and y coordinates extracted from the active state’s crystal structure (PDB id: 3SN6). b Side and (c) intracellular views of 20 snapshots colored from red (initial), to white (intermediate), to blue (final) during simulationBack to article page