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Fig. 7 | BMC Structural Biology

Fig. 7

From: Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3

Fig. 7

Results of 500 ns long rstr4 run. The expected ICL3 closure was observed under 100 ns, when an additional bond restraint was imposed between the backbone atoms in the ligand-binding site. a ICL3’s center of mass (x and y only) color-coded by time step. Lines represent the G protein’s a helix x and y coordinates extracted from the active state’s crystal structure (PDB id: 3SN6). b Side and (c) intracellular views of 20 snapshots colored from red (initial), to white (intermediate), to blue (final) during simulation

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