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Fig. 8 | BMC Structural Biology

Fig. 8

From: Investigation of allosteric coupling in human β2-adrenergic receptor in the presence of intracellular loop 3

Fig. 8

Results of the fifth restrained rstr5 run. Here, the bond restraints narrowed the ligand-binding site region while ICL3 was completely packed. The initially packed/closed state of ICL3 was preserved throughout 500 ns long simulation. a The initial (red) and final (blue) snapshots of MD run, (b) ICL3’s center of mass (x and y only) color-coded by time step, where lines represent the G protein’s a helix x and y coordinates extracted from the active state’s crystal structure (PDB id: 3SN6)

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