Fig. 10
Asymmetry statistics for like/mixed domain pairs. Given the ranked list of domain pairings, the chance for more domain pairs of like-type to be found higher than the observed order was evaluated from empirical distributions measured by two statistics: the second moment of the rank value (red) and the number of like-type pairs in the top half (blue). These statistics were calculated for all subsets from the 6 top pairs up to the full set of comparisons (X-axis) and for each, the chance of a better score is plotted as the log 10 of the probability (Y-axis). The horizontal lines mark the 0.5, 0.05 and 0.005 levels. The line at the 0.001 level is coloured by the Z-score for each pair as: green = over 3 and cyan = over 4 sigma. Part (a) shows the probabilities calculated from the full set of 7 carboxy and 12 amino domains and part (b) shows the same values calculated on a more balanced set of 5 non-redundant carboxy domains and their matching amino domains