Fig. 9

ortho-C and foamy-N domain comparison statistics. The a-value (normalised RMSD) for the comparison of the ortho-C and foamy-N decoy domains (Fig. 8 b) are plotted as a frequency distribution (red) along with a bell-shaped Normal distribution curve (green) with matching mean (μ) and spread (σ). Part (a) shows the distribution for the HIV1 C-terminal domain (μ=1.23) and spread (σ=0.17) with the position of the native structure comparison plotted as a blue (inverted) triangle. Its position lies 0.64 units below the mean giving a Z-score of 0.64/0.17=3.76. Part (b) shows the combined data from seven representative viruses (in Table 1). These data comprise two distributions, that of the combined decoys and also the much smaller distribution of native scores (blue triangles). This allows a T-test to be made on the significance of their separation