Fig. 6

Characterization of SNPs in the hCNT3 homotrimer model. Residues to which non-synonymous mutations refer were shown as red balls, residues referring to synonymous mutations were shown as yellow balls. The left panel: a single hCNT3 subunit with uridine (green balls) and sodium ion (violet ball) which were transferred from the vcCNT template structure and placed in the same position and orientation. The right panel: the entire hCNT3 homotrimer model with the schematic lipid bilayer (red and blue dots). The right bottom panel: the heavy atoms RMSD plot computed for the MD simulation trajectory with respect to the first frame. RMSD was computed for two residues sets – referring to synonymous mutations and to non-synonymous mutations