Fig. 3

Three- dimensional models and topology of (1) huMTAP (pdb: 1CG6), (2) LiMTAP and (3) TbMTAP. a The cartoon representation of the 3D models integrates the MEME motifs, which are represented in different colors: yellow for the conserved MEME motifs and red for the parasite specific ones. The protein parts that do not include a MEME motif are colored in grey. The secondary structure elements are labeled on each MTAP model. The N- and C- terminal extremities are marked by N and C, respectively. b Only the topology diagrams of (1) huMTAP and (2) LiMTAP are displayed as the TbMTAP diagram is identical to the LiMTAP one. On these diagrams, the α-helices and β-strands are shown by red cylinders and blue arrows, respectively, and are labeled by numbers starting from the N- terminal extremity. The first and last amino acids of each secondary structure are shown on the corresponding shape, on both huMTAP (1) and LiMTAP (2) diagrams. The connector coils are shown as blue lines. On the parasite protein topology diagrams, the α7 helix brings the C- terminal extremity in a spatially close position to the N- terminus