Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

Table 1 Data related to the ten structural analogs of Li (a) and Tb (b) MTAP 3D models identified by I-TASSER

PDB ID	Protein	Ligand	Protein stoichiometry	Organism	TM-score (a)	RMSD (a)	TM-score (b)	RMSD (b)
4GLF	MTAP	–	Homo trimer	Cultured bacterium	0.929	0.53	0.919	0.56
1WTA	MTAP	ADE + PO₄	Homo trimer	Aeropyrum pernix	0.830	1.84	0.826	1.84
1V4N	MTAP	–	Homo trimer	Sulfolobus tokodai	0.828	1.82	0.822	1.77
3 T94	MTAP	MTA + SO₄	Homo hexamer	Sulfolobus solfataricus	0.821	1.87	0.814	1.86
3OZC	MTAP	4CT + PO₄	Homo trimer	Homo sapiens	0.811	1.91	0.805	1.89
4L5A	MTAP	TBN + SO₄	Homo trimer	Schistosoma mansoni	0.805	2.19	0.798	2.07
3OZB	MTAP	HPA + SO₄	Homo hexamer	Pseudomonas aeruginosa	0.744	1.73	0.738	1.71
1TCV	PNP	NDS + ACT	Homo trimer	Schistosoma mansoni	0.715	2.97	0.712	2.99
2P4S	PNP	DIH + PO₄	Homo trimer	Anopheles gambiae	0.711	2.98	0.707	3.02
1A9O	PNP	PO₄	Homo trimer	Bos taurus	0.709	3.05	0.707	3.22

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