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Table 1 Data related to the ten structural analogs of Li (a) and Tb (b) MTAP 3D models identified by I-TASSER

From: Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

PDB ID Protein Ligand Protein stoichiometry Organism TM-score (a) RMSD (a) TM-score (b) RMSD (b)
4GLF MTAP Homo trimer Cultured bacterium 0.929 0.53 0.919 0.56
1WTA MTAP ADE + PO4 Homo trimer Aeropyrum pernix 0.830 1.84 0.826 1.84
1V4N MTAP Homo trimer Sulfolobus tokodai 0.828 1.82 0.822 1.77
3 T94 MTAP MTA + SO4 Homo hexamer Sulfolobus solfataricus 0.821 1.87 0.814 1.86
3OZC MTAP 4CT + PO4 Homo trimer Homo sapiens 0.811 1.91 0.805 1.89
4L5A MTAP TBN + SO4 Homo trimer Schistosoma mansoni 0.805 2.19 0.798 2.07
3OZB MTAP HPA + SO4 Homo hexamer Pseudomonas aeruginosa 0.744 1.73 0.738 1.71
1TCV PNP NDS + ACT Homo trimer Schistosoma mansoni 0.715 2.97 0.712 2.99
2P4S PNP DIH + PO4 Homo trimer Anopheles gambiae 0.711 2.98 0.707 3.02
1A9O PNP PO4 Homo trimer Bos taurus 0.709 3.05 0.707 3.22