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Table 2 Functional or structural correlation of MEME sequence motifs found in huMTAP, LiMTAP, TbMTAP and huPNP

From: Leishmania infantum 5’-Methylthioadenosine Phosphorylase presents relevant structural divergence to constitute a potential drug target

Motif Involved secondary structures Structural/functional significance in NP-I family (a)
Common MTAP motifs
 M1 α3, β10, α4, β11 Involved in active site and trimeric contacts
 M2 β3, β4, part of α1 Involved in active site
 M3 β5, β6, β7 Involved in active site and trimeric contacts
 M6 β8, β9  
Parasite specific motifs
 M5 β1 Involved in active site
 M7 part of α2  
 M4 α5, α6  
 M8 α7  
  1. (a)Reviewed by Pugmire and Ealick [15]