Table 2 Functional or structural correlation of MEME sequence motifs found in huMTAP, LiMTAP, TbMTAP and huPNP
Motif | Involved secondary structures | Structural/functional significance in NP-I family (a) |
|---|---|---|
Common MTAP motifs | ||
M1 | α3, β10, α4, β11 | Involved in active site and trimeric contacts |
M2 | β3, β4, part of α1 | Involved in active site |
M3 | β5, β6, β7 | Involved in active site and trimeric contacts |
M6 | β8, β9 | |
Parasite specific motifs | ||
M5 | β1 | Involved in active site |
M7 | part of α2 | |
M4 | α5, α6 | |
M8 | α7 | |