Table 4 Residues involved with HETA binding to the three MTAPs
huMTAP | – | – | T18 | – | – | H65 | – | P69 | – | – | A94 | C95 | G96 | F177 | I194 | N195 | M196 | T197 | T219 | D220 | D222 | – | – | – | V231 | V236 | – | – | – |
Li MTAP | G16 | G17 | – | R60 | H61 | H65 | N68 | P69 | I92 | N93 | A94 | – | – | F181 | – | G199 | M200 | T201 | – | – | – | M221 | – | M243 | – | – | – | – | – |
Tb MTAP | – | G18 | – | – | H62 | H66 | – | – | V93 | N94 | A95 | V96 | – | F185 | – | – | M204 | – | – | – | – | A225 | T227 | M247 | – | – | N250 | V251 | V254 |
MEME motifs | 5 | 5 | – | 2 | 2 | 2 | 2 | 2 | 3 | 3 | 3 | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | – | – | 4 | 4 | 4 |