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Table 3 Average evolutionary conservation of amino acid residues important for SOD1 structure and function

From: Molecular mechanisms underlying the impact of mutations in SOD1 on its conformational properties associated with amyotrophic lateral sclerosis as revealed with molecular modelling

Residue list Mean evolutionary conservations of residues from list Significance of difference from mean evolutionary conservation over all protein residues
All residues −1.3*10−5 (≈0)
Residues forming destructive hydrogen bonds 0.3 0.05
Residues with increased mechanical stiffness to copper 0.57 8.1*10−4
Residues with top mean stiffness to all residues 0.64 0.013