Fig. 3
From: A structural preview of aquaporin 8 via homology modeling of seven vertebrate isoforms
Structural conservation of Cα positions in AQPs mapped onto the structure of AtTIP2;1. The result of structural alignment of 49 deposited AQP structures from the PDB is indicated on the AtTIP2;1 structure. Thin (blue) putty indicates high degree of structural conservation, while thick (red) putty indicates low degree of structural conservation. In general, transmembrane helices are highly conserved, while loops are more variable. The longest loop in the upper part of the picture, loop C, has a high degree of variance at the N-terminal end (right), while the LCP (middle) and the fold at the C-terminal region (left) before helix 4 is more conserved. PDB IDs are provided in Additional file 6