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Table 1 Summary comparison of virulence factor candidates from whole genome sequencing and corresponding Phyre2-modeled proteins

From: Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum, the causative agent of syphilis

Protein Genome Annotation [8] Phyre2 Model Templates: 1st rank model and potential virulence model(s)
TPANIC_0027 Putative hemolysin (HlyC) 1st rank: CorC Magnesium/Cobalt efflux protein (E. coli)
5th rank: Hemolysin-like protein (Oenococcus oeni)
TPANIC_0028 Putative hemolysin (HlyC) 1st rank: CorC Magnesium/Cobalt efflux protein (E. coli)
5th rank: Hemolysin-like protein (Oenococcus oeni)
TPANIC_0399 Type 3 (virulence-related)
Secretory pathway protein
(FliF)
1st rank: PrgH (Salmonella typhimurium type 3 secretion system protein)
2nd rank: EscJ (E. coli Type 3 secretion system protein)
TPANIC_0401 Type 3 (virulence-related)
Secretory pathway protein
(FliH)
1st rank: V-type proton ATPase subunit E (yeast)
No potential virulence models
TPANIC_0402 Type 3 (virulence-related)
Secretory pathway protein
(FliL)
1st rank: Flagellar type 3 ATPase FliI (Salmonella enterica)
No potential virulence models
TPANIC_0649 Putative hemolysin (TlyC) 1st rank: CorC Magnesium/Cobalt efflux protein (E. coli) 5th rank: Hemolysin-like protein (Oenococcus oeni)
TPANIC_0714 Type 3 (virulence-related)
secretory pathway protein
(FlhA)
1st rank: Flagellar biosynthesis protein FlhA (Helicobacter pylori)
3rd rank: InvA (S. enterica type 3 secretion system invasion protein)
5th rank: MxiA (Shigella flexneri type 3 secretion system invasion protein)
TPANIC_0715 Type 3 (virulence-related)
secretory pathway protein
(FlhB)
1st rank: YscU (Y. pestis type 3 secretion system protein)
2nd rank: EscU (E. coli type 3 secretion system protein)
3rd rank: EscU (E. coli type 3 secretion system protein)
TPANIC_0936 Putative hemolysin 1st rank: CorC Magnesium/Cobalt efflux protein (E. coli) 5th rank: Hemolysin-like protein (Oenococcus oeni)
TPANIC_1037 Putative hemolysin III (HlyIII) 1st rank: Human adiponectin receptor 1