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Table 1 Summary comparison of virulence factor candidates from whole genome sequencing and corresponding Phyre2-modeled proteins

From: Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum, the causative agent of syphilis

Protein

Genome Annotation [8]

Phyre2 Model Templates: 1st rank model and potential virulence model(s)

TPANIC_0027

Putative hemolysin (HlyC)

1st rank: CorC Magnesium/Cobalt efflux protein (E. coli)

5th rank: Hemolysin-like protein (Oenococcus oeni)

TPANIC_0028

Putative hemolysin (HlyC)

1st rank: CorC Magnesium/Cobalt efflux protein (E. coli)

5th rank: Hemolysin-like protein (Oenococcus oeni)

TPANIC_0399

Type 3 (virulence-related)

Secretory pathway protein

(FliF)

1st rank: PrgH (Salmonella typhimurium type 3 secretion system protein)

2nd rank: EscJ (E. coli Type 3 secretion system protein)

TPANIC_0401

Type 3 (virulence-related)

Secretory pathway protein

(FliH)

1st rank: V-type proton ATPase subunit E (yeast)

No potential virulence models

TPANIC_0402

Type 3 (virulence-related)

Secretory pathway protein

(FliL)

1st rank: Flagellar type 3 ATPase FliI (Salmonella enterica)

No potential virulence models

TPANIC_0649

Putative hemolysin (TlyC)

1st rank: CorC Magnesium/Cobalt efflux protein (E. coli) 5th rank: Hemolysin-like protein (Oenococcus oeni)

TPANIC_0714

Type 3 (virulence-related)

secretory pathway protein

(FlhA)

1st rank: Flagellar biosynthesis protein FlhA (Helicobacter pylori)

3rd rank: InvA (S. enterica type 3 secretion system invasion protein)

5th rank: MxiA (Shigella flexneri type 3 secretion system invasion protein)

TPANIC_0715

Type 3 (virulence-related)

secretory pathway protein

(FlhB)

1st rank: YscU (Y. pestis type 3 secretion system protein)

2nd rank: EscU (E. coli type 3 secretion system protein)

3rd rank: EscU (E. coli type 3 secretion system protein)

TPANIC_0936

Putative hemolysin

1st rank: CorC Magnesium/Cobalt efflux protein (E. coli) 5th rank: Hemolysin-like protein (Oenococcus oeni)

TPANIC_1037

Putative hemolysin III (HlyIII)

1st rank: Human adiponectin receptor 1