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Table 2 Genome sequencing annotated proteins with potential novel virulence-related functions identified by Phyre2 modeling

From: Functional insights from proteome-wide structural modeling of Treponema pallidum subspecies pallidum, the causative agent of syphilis


Genome Annotation

Phyre2 Models: 1st rank model and potential virulence model(s)


Cyclic nucleotide-binding protein

1st rank: PrfA (Listeria monocytogenes virulence factor transcriptional regulator)


Peptidylprolyl isomerase (FklB)

1st rank: Mip (Legionella pneumophila macrophage infectivity potentiator protein)

5th rank: Tcmip (Trypanosoma cruzi macrophage infectivity potentiator protein)


Patatin family phospholipase

1st rank: VipD (Legionella pneumophila phospholipase effector protein)

2nd rank: ExoU (Pseudomonas aeruginosa type 3 secretion system effector protein)