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Table 3 Predicted and measured changes in heat stability for various P2 variants. Tm values for P38G and the disease mutations have been published [11, 25]

From: Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins

variant

Cupsat ∆∆G (kcal/mol)

MAESTRO ∆∆G (kcal/mol)

Experimental ∆Tm (°C)

F57A

−1.91

1.16

−6

P38G

−5.38

1.64

−6

I43N

−7.63

3.92

−17

T51P

−1.51

1.43

−24

I52T

−5.17

2.89

−13

  1. Note that Cupsat defines a destabilizing mutation with a negative ∆∆G, while in MAESTRO, a destabilizing mutation has a positive ∆∆G
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BMC Structural Biology

ISSN: 1472-6807

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