Table 1 RIN clusters in WT and amyloidogenic variants of lysozyme
Lysozyme Structure | Cluster Rank | MCODE Score | Residues Involved | Average Residue B-Factor |
|---|---|---|---|---|
WT | 14.88 | |||
1 | 6.36 | 92–103 | 12.35 | |
2 | 6.00 | 32–37 | 11.71 | |
3 | 5.60 | 7–13, 19, 23–29, 31 | 9.72 | |
4 | 5.11 | 104, 106–108, 112–117 | 19.09 | |
I56T | 16.06 | |||
1 | 6.00 | 112–117 | 17.53 | |
2 | 6.00 | 92–98 | 10.54 | |
3 | 5.60 | 7–13, 19, 23–29, 31 | 10.39 | |
4 | 5.00 | 122–126 | 29.15 | |
D67H | 13.24 | |||
1 | 6.50 | 92–100 | 7.83 | |
2 | 6.00 | 112–117 | 14.99 | |
3 | 6.00 | 32–37 | 8.21 | |
4 | 5.75 | 7–13, 17–19, 23, 25–29, 31 | 8.12 |