In silico prediction of novel residues involved in amyloid primary nucleation of human I56T and D67H lysozyme

BMC Structural Biology

Table 1 RIN clusters in WT and amyloidogenic variants of lysozyme

Lysozyme Structure	Cluster Rank	MCODE Score	Residues Involved	Average Residue B-Factor
WT				14.88
	1	6.36	92–103	12.35
	2	6.00	32–37	11.71
	3	5.60	7–13, 19, 23–29, 31	9.72
	4	5.11	104, 106–108, 112–117	19.09
I56T				16.06
	1	6.00	112–117	17.53
	2	6.00	92–98	10.54
	3	5.60	7–13, 19, 23–29, 31	10.39
	4	5.00	122–126	29.15
D67H				13.24
	1	6.50	92–100	7.83
	2	6.00	112–117	14.99
	3	6.00	32–37	8.21
	4	5.75	7–13, 17–19, 23, 25–29, 31	8.12

ISSN: 1472-6807