Fig. 4

Unique features of trypanosoma eIF1A. a Homology model of Trypanosoma vivax eIF1A (left) and human eIF1A structure (right) colored by charge/hydrophobicity. The structures are in the same orientation as in Fig. 1. Trypanosoma-specific hydrophobic residues are shown in green; a unique hydrophobic surface is circled; and a hydrophobic segment in the C-terminus of T. vivax eIF1A is shown in ribbon as an inset in the left panel. b Functionally important surfaces of eIF1A are shown as a reference. Intermolecular interaction surfaces (left) are color-coded and labeled as in Fig. 2a. The intermolecular contact surface for eIF1A-CTT is shown on the right panel. The area corresponding to the Trypanosoma-specific hydrophobic surface is circled as in panel a