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Fig. 4 | BMC Structural Biology

Fig. 4

From: Crystal structure of carbonic anhydrase CaNce103p from the pathogenic yeast Candida albicans

Fig. 4

Crystal structures of carbonic anhydrase Δ29_CaNce103p. (a) Overall structure of Δ29_CaNce103p illustrating the tetrameric assembly. The tetramer is shown with chains A, B, C (red, blue, cyan) in surface representation and chain D (green) in cartoon representation. (b) Δ29_CaNce103p monomer. Secondary structure elements are labeled, and the positions of the N- and C-terminus are indicated. The Zn2+ ions are shown as red spheres. Coordinating His160, Cys106, Cys163 and β-mercaptoethanol (blue sticks) are only shown for the D chain. (c) Close-up view of superposition of the N-terminal arms of Δ29_CaNce103p (green), ScNce103 (red), CAS1 (blue) and Can2 (magenta). The first two conserved α-helices (α1 and α2) are shown in cartoon representation. The C-terminal subdomain of the second molecule of Δ29_CaNce103p in the asymmetric unit is shown in surface representation (gray). (d) Detailed structure of the active site in stick representation. Numbers indicate distances in Å for the contacts, shown as black dashed lines. The 2Fo-Fc electron-density map is contoured at 2.0 σ in blue

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