Fig. 3
From: Deciphering evolution of immune recognition in antibodies
Mapping somatic mutations on sequences and structures of antibodies of VH1–84 lineage. a Multiple sequence alignment of the variable region of heavy chain of mature antibodies with the germline sequence. Mutations in the CDRs and FW regions are highlighted in red. b Frequency of VH mutations and percent identity with corresponding germline sequence. c Stereo view of ribbon representation of structure superposition of free antibodies (last structure of simulation) showing the mutated residues of VH region in sticks. Stereo view of ribbon representation of structure superposition of respective free antibodies (last structure of simulation) and bound forms (crystal structures) of (d) Fab ED10 (PDB ID: 2OK0), (e) Fab 5.11A1 (PDB ID: 1YJD) and (f) anti-uPAR (PDB ID: 3BT2) antibody