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Table 1 Widely varying structural classes of the proteins selected for experimentation

From: An improved protein structure evaluation using a semi-empirically derived structure property

PDB id Protein name Class Fold Super family Family Duplication Species
1ao6 Serum albumin All alpha proteins Serum albumin-like multihelical; one domain consists of two similar disulfide-linked subdomains Serum albumin link to SUPERFAMILY database - Superfamily Serum albumin consists of three domains of this fold Human (Homo sapiens)
1new Cytochrome c7 (cytochrome c551.5, PpcA)contains three heme groups; deletion of one of Cyt c3 heme-binding sites All alpha proteins Multiheme cytochromes variable number of helices and little beta structure; not a true fold Multiheme cytochromes Cytochrome c3 contains multiple CxxCH motifs
link to SUPERFAMILY
Desulfuromonas acetoxidans
1ro3 Echistatin Small proteins Usually dominated by metal ligand, heme, and/or disulfide bridges Blood coagulation inhibitor (disintegrin) small disulfide-rich Blood coagulation inhibitor (disintegrin)
link to SUPERFAMILY database - Superfamily
Blood coagulation inhibitor (disintegrin) Not Reported Saw-scaled viper (Echis carinatus)
2vb1 Lysozyme ubiquitous in a variety of tissues and secretions Alpha and beta proteins Mainly antiparallel beta sheets (segregated alpha and beta regions) Lysozyme-like common alpha+beta motif for the active site region Lysozyme-like Superfamily C-type lysozyme Not Reported Chicken (Gallus gallus)
2h8b Insulin from Human (in absence of report for 2h8b other columns were filled in for 1ben) Small proteins (hormone) Insulin-like nearly all-alpha
can be classified as disulfide-rich
Insulin-like link to SUPERFAMILY database - Superfamily Insulin Not Reported Human (Homo sapiens)
1a3n Hemoglobin, alpha-chain from Human All alpha proteins Globin-like core: 6 helices; folded leaf, partly opened Globin-like link to SUPERFAMILY database - Superfamily Globins Heme-binding protein Not Reported Human (Homo sapiens)