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Fig. 2 | BMC Structural Biology

Fig. 2

From: The human transketolase-like proteins TKTL1 and TKTL2 are bona fide transketolases

Fig. 2

Homology of TKTL1. Homology model of TKTL1 based on the TKT co-crystal structure with a TDP-D-xylulose-5-phosphate (X5P) adduct. a Ribbon representation of the homodimer (tan and blue sub-units) of TKT with the TDP-X5P adduct ligand shown as red spheres. The η1, α4 and η2 helices (green), as well as H77 and H110 (yellow) (absent in TKTL1) are shown. b Homology model of TKTL1 shown as a homodimer (tan and blue sub-units) and fitted to the coordinates of TKT to show the location of the substrate adduct, indicated by the red spheres. c The ligand present in the substrate cleft that is formed between the surfaces of the two units in the TKT homodimer is shown. d A similar substrate cleft is visible between the two units of the homodimer in the homology model of TKTL1. e A di-phosphate binding cavity in visible on the surface within the substrate cleft of each monomer in the TKT homodimer. f A di-phosphate binding cavity is also visible within the substrate cleft of the TKTL1 homology model

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