Table 1 B cell epitopes of the PvMSP3 block II from the database https://www.iedb.org/: the location of epitopes, amino acid substitutions and the proportion of the variable amino acids were stated as observed by aligning 142 amino acid sequences from 18 populations
Epitope (IEDB) | Region Found | Position & Variable residues (substitutions) | % Proportion |
|---|---|---|---|
1) NDATEAKKQAEKAKAAAEEAKTHGEK | LCR | 1 K/N/H/E | 68.6/28.7/1.1/1.1 |
8 E/K | 79.8/19.7 | ||
2) KAYAVEAHLAKTKN | HCR | Singletons Only | |
3) DAANIAHQKWLKAT | HCR | Conserved Region | |
4) KAQKEATAAKLKA | LCR | 134 A/T | 95.7/3.7 |
136 T/K/N/A | 54.8/43.6/0.5/0.5 | ||
137 A/E | 55.9/43.6 | ||
139 N/T | 54.8/44.7 | ||
140 V/A | 55.9/43.6 | ||
141 V/A | 55.9/43.6 | ||
143 D/L/F | 54.8/44.1 | ||
5) AEDAAEEAKEAAKK | LCR | 212 A/V | 94.1/5.9 |
215 A/T/P | 98.4/1.1 | ||
6) DKTIAAAKKAKKARE | LCR | 234 K/N | 97.3/2.7 |
235 A/T | 98.4/1.6 | ||
236 I/M | 98.9/1.1 |