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  1. Content type: Research article

    Microsomal CYP2E1 metabolizes about 160 hydrophobic exogens, many of which are environmental pollutants. While metabolising xenobiotics CYP2E1 on one hand facilitates in their excretion and on the other hand a...

    Authors: Volodymyr O Kitam, Oksana V Maksymchuk and Mykola O Chashchyn

    Citation: BMC Structural Biology 2012 12:33

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  2. Content type: Research article

    Human farnesyl pyrophosphate synthase (FPPS) controls intracellular levels of farnesyl pyrophosphate, which is essential for various biological processes. Bisphosphonate inhibitors of human FPPS are valuable t...

    Authors: Jaeok Park, Yih-Shyan Lin, Joris W De Schutter, Youla S Tsantrizos and Albert M Berghuis

    Citation: BMC Structural Biology 2012 12:32

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  3. Content type: Software

    With the progress of nanotechnology, one frequently has to model biological macromolecules simultaneously with nano-objects. However, the atomic structures of the nano objects are typically not available or th...

    Authors: Nicholas Smith, Brandon Campbell, Lin Li, Chuan Li and Emil Alexov

    Citation: BMC Structural Biology 2012 12:31

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  4. Content type: Research article

    Toxoplasma gondii is an intracellular coccidian parasite that causes toxoplasmosis. It was estimated that more than one third of the world population is infected by T. gondii, and the disease is critical in fetus...

    Authors: Yap Boon Wooi Tommy, Theam Soon Lim, Rahmah Noordin, Geita Saadatnia and Yee Siew Choong

    Citation: BMC Structural Biology 2012 12:30

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  5. Content type: Methodology article

    MTMDAT is a program designed to facilitate analysis of mass spectrometry data of proteins and biomolecular complexes that are probed structurally by limited proteolysis. This approach can provide information a...

    Authors: Janosch Hennig, Sjoerd J de Vries, Klaus DM Hennig, Leah Randles, Kylie J Walters, Maria Sunnerhagen and Alexandre MJJ Bonvin

    Citation: BMC Structural Biology 2012 12:29

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  6. Content type: Research article

    Interaction of non-structural protein 5A (NS5A) of Hepatitis C virus (HCV) with human kinases namely, casein kinase 1α (ck1α) and protein kinase R (PKR) have different functional implications such as regulatio...

    Authors: Govindarajan Sudha, Subburaj Yamunadevi, Nidhi Tyagi, Saumitra Das and Narayanaswamy Srinivasan

    Citation: BMC Structural Biology 2012 12:28

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  7. Content type: Research article

    P-type ATPases hydrolyze ATP and release energy that is used in the transport of ions against electrochemical gradients across plasma membranes, making these proteins essential for cell viability. Currently, t...

    Authors: Lorena Novoa-Aponte, Andrés León-Torres, Miyer Patiño-Ruiz, Jenifer Cuesta-Bernal, Luz-Mary Salazar, David Landsman, Leonardo Mariño-Ramírez and Carlos-Yesid Soto

    Citation: BMC Structural Biology 2012 12:25

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  8. Content type: Research article

    Bacteria such as Escherichia coli and Salmonella typhimurium can utilize acetate as the sole source of carbon and energy. Acetate kinase (AckA) and phosphotransacetylase (Pta), key enzymes of acetate utilization ...

    Authors: Sagar Chittori, Handanahal S Savithri and Mathur RN Murthy

    Citation: BMC Structural Biology 2012 12:24

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  9. Content type: Research article

    HutZ is the sole heme storage protein identified in the pathogenic bacterium Vibrio cholerae and is required for optimal heme utilization. However, no heme oxygenase activity has been observed with this protein. ...

    Authors: Xiuhua Liu, Jing Gong, Tiandi Wei, Zhi Wang, Qian Du, Deyu Zhu, Yan Huang, Sujuan Xu and Lichuan Gu

    Citation: BMC Structural Biology 2012 12:23

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  10. Content type: Research article

    Structure-based drug design (SBDD) can accelerate inhibitor lead design and optimization, and efficient methods including protein purification, characterization, crystallization, and high-resolution diffractio...

    Authors: Maria A Argiriadi, Eric R Goedken, David Banach, David W Borhani, Andrew Burchat, Richard W Dixon, Doug Marcotte, Gary Overmeyer, Valerie Pivorunas, Ramkrishna Sadhukhan, Silvino Sousa, Nigel St John Moore, Medha Tomlinson, Jeffrey Voss, Lu Wang, Neil Wishart…

    Citation: BMC Structural Biology 2012 12:22

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  11. Content type: Research article

    The inhibition of the activity of β-secretase (BACE-1) is a potentially important approach for the treatment of Alzheimer disease. To explore the mechanism of inhibition, we describe the use of 46 X-ray crysta...

    Authors: Shu Liu, Rao Fu, Xiao Cheng, Sheng-Ping Chen and Li-Hua Zhou

    Citation: BMC Structural Biology 2012 12:21

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  12. Content type: Research article

    HLA-DPs are class II MHC proteins mediating immune responses to many diseases. Peptides bind MHC class II proteins in the acidic environment within endosomes. Acidic pH markedly elevates association rate const...

    Authors: Atanas Patronov, Ivan Dimitrov, Darren R Flower and Irini Doytchinova

    Citation: BMC Structural Biology 2012 12:20

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  13. Content type: Research article

    S100 proteins are a family of small, EF-hand containing calcium-binding signaling proteins that are implicated in many cancers. While the majority of human S100 proteins share 25-65% sequence similarity, S100A...

    Authors: Jill I Murray, Michelle L Tonkin, Amanda L Whiting, Fangni Peng, Benjamin Farnell, Jay T Cullen, Fraser Hof and Martin J Boulanger

    Citation: BMC Structural Biology 2012 12:16

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  14. Content type: Research article

    Dihydroxylation of tandemly linked aromatic carbons in a cis-configuration, catalyzed by multicomponent oxygenase systems known as Rieske nonheme iron oxygenase systems (ROs), often constitute the initial step of...

    Authors: Yuji Ashikawa, Zui Fujimoto, Yusuke Usami, Kengo Inoue, Haruko Noguchi, Hisakazu Yamane and Hideaki Nojiri

    Citation: BMC Structural Biology 2012 12:15

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  15. Content type: Research article

    Aspartyl aminopeptidase (DNPEP), with specificity towards an acidic amino acid at the N-terminus, is the only mammalian member among the poorly understood M18 peptidases. DNPEP has implicated roles in protein ...

    Authors: Apirat Chaikuad, Ewa S Pilka, Antonio De Riso, Frank von Delft, Kathryn L Kavanagh, Catherine Vénien-Bryan, Udo Oppermann and Wyatt W Yue

    Citation: BMC Structural Biology 2012 12:14

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  16. Content type: Research article

    Type III secretion systems are used by Gram-negative bacteria as “macromolecular syringes” to inject effector proteins into eukaryotic cells. Two hydrophobic proteins called translocators form the necessary po...

    Authors: Madeleine Schreiner and Hartmut H Niemann

    Citation: BMC Structural Biology 2012 12:13

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  17. Content type: Research article

    Capping protein (CP), also known as CapZ in muscle cells and Cap32/34 in Dictyostelium discoideum, plays a major role in regulating actin filament dynamics. CP is a ubiquitously expressed heterodimer comprising a...

    Authors: Christian Eckert, Agnieszka Goretzki, Maria Faberova and Martin Kollmar

    Citation: BMC Structural Biology 2012 12:12

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  18. Content type: Research article

    The detection of conserved residue clusters on a protein structure is one of the effective strategies for the prediction of functional protein regions. Various methods, such as Evolutionary Trace, have been de...

    Authors: Wataru Nemoto and Hiroyuki Toh

    Citation: BMC Structural Biology 2012 12:11

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  19. Content type: Research article

    Modular polyketide synthases are multifunctional megasynthases which biosynthesize a variety of secondary metabolites using various combinations of dehydratase (DH), ketoreductase (KR) and enoyl-reductase (ER)...

    Authors: Swadha Anand and Debasisa Mohanty

    Citation: BMC Structural Biology 2012 12:10

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  20. Content type: Commentary

    Small-angle scattering is becoming an increasingly popular tool for the study of bio-molecular structures in solution. The large number of publications with 3D-structural models generated from small-angle solu...

    Authors: David A Jacques, Jules Mitchell Guss and Jill Trewhella

    Citation: BMC Structural Biology 2012 12:9

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  21. Content type: Research article

    Tumor necrosis factors, TNF and lymphotoxin-α (LT), are cytokines that bind to two receptors, TNFR1 and TNFR2 (TNF-receptor 1 and 2) to trigger their signaling cascades. The exact mechanism of ligand-induced r...

    Authors: Nahren Manuel Mascarenhas and Johannes Kästner

    Citation: BMC Structural Biology 2012 12:8

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  22. Content type: Research article

    Influenza neuraminidase (NA) is an important target for antiviral inhibitors since its active site is highly conserved such that inhibitors can be cross-reactive against multiple types and subtypes of influenz...

    Authors: Lalitha Venkatramani, Eric S Johnson, Gundurao Kolavi, Gillian M Air, Wayne J Brouillette and Blaine HM Mooers

    Citation: BMC Structural Biology 2012 12:7

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  23. Content type: Research article

    Most signalling and regulatory proteins participate in transient protein-protein interactions during biological processes. They usually serve as key regulators of various cellular processes and are often stabl...

    Authors: Lakshmipuram S Swapna, Swapnil Mahajan, Alexandre G de Brevern and Narayanaswamy Srinivasan

    Citation: BMC Structural Biology 2012 12:6

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  24. Content type: Research article

    Structural genomics approaches, particularly those solving the 3D structures of many proteins with unknown functions, have increased the desire for structure-based function predictions. However, prediction of ...

    Authors: Keisuke Ueno, Katsuhiko Mineta, Kimihito Ito and Toshinori Endo

    Citation: BMC Structural Biology 2012 12:5

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  25. Content type: Research article

    Plasmodium falciparum is the protozoan parasite primarily responsible for more than one million malarial deaths, annually, and is developing resistance to current therapies. Throughout its lifespan, the parasite ...

    Authors: Wei Qiu, Aiping Dong, Juan C Pizarro, Alexei Botchkarsev, Jinrong Min, Amy K Wernimont, Tanya Hills, Raymond Hui and Jennifer D Artz

    Citation: BMC Structural Biology 2012 12:2

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  26. Content type: Research article

    Protein-DNA interactions play a crucial role in the life of biological organisms in controlling transcription, regulation, as well as DNA recombination and repair. The deep understanding of these processes, wh...

    Authors: Paul Garcin, Olivier Delalande, Ju-Yuan Zhang, Corinne Cassier-Chauvat, Franck Chauvat and Yves Boulard

    Citation: BMC Structural Biology 2012 12:1

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  27. Content type: Research article

    Halophiles are extremophilic microorganisms growing optimally at high salt concentrations. There are two strategies used by halophiles to maintain proper osmotic pressure in their cytoplasm: accumulation of mo...

    Authors: Alessandro Siglioccolo, Alessandro Paiardini, Maria Piscitelli and Stefano Pascarella

    Citation: BMC Structural Biology 2011 11:50

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  28. Content type: Research article

    Cyclophilin A (CypA) represents a potential key molecule in future antiretroviral therapy since inhibition of CypA suppresses human immunodeficiency virus type 1 (HIV-1) replication. CypA interacts with the vi...

    Authors: Sara MØ Solbak, Victor Wray, Ole Horvli, Arnt J Raae, Marte I Flydal, Petra Henklein, Peter Henklein, Manfred Nimtz, Ulrich Schubert and Torgils Fossen

    Citation: BMC Structural Biology 2011 11:49

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  29. Content type: Research article

    tRNA m1A58 methyltransferases (TrmI) catalyze the transfer of a methyl group from S-adenosyl-L-methionine to nitrogen 1 of adenine 58 in the T-loop of tRNAs from all three domains of life. The m1A58 modification ...

    Authors: Amandine Guelorget, Pierre Barraud, Carine Tisné and Béatrice Golinelli-Pimpaneau

    Citation: BMC Structural Biology 2011 11:48

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  30. Content type: Research article

    Fluoroquinolone resistance is a serious threat in the battle against the treatment of multi drug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB). Fluoroquinolone resistant ...

    Authors: RS Anand, Sulochana Somasundaram, Mukesh Doble and CN Paramasivan

    Citation: BMC Structural Biology 2011 11:47

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  31. Content type: Methodology article

    The simulation of protein unfolding usually requires recording long molecular dynamics trajectories. The present work aims to figure out whether NMR restraints data can be used to probe protein conformations i...

    Authors: Nathalie Duclert-Savatier, Leandro Martínez, Michael Nilges and Thérèse E Malliavin

    Citation: BMC Structural Biology 2011 11:46

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  32. Content type: Research article

    Structural insight from transcription factor-DNA (TF-DNA) complexes is of paramount importance to our understanding of the affinity and specificity of TF-DNA interaction, and to the development of structure-ba...

    Authors: RyangGuk Kim, Rosario I Corona, Bo Hong and Jun-tao Guo

    Citation: BMC Structural Biology 2011 11:45

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  33. Content type: Research article

    How proteins approach surrounding molecules is fundamental to our understanding of the specific interactions that occur at the surface of proteins. The enhanced surface accessibility of small molecules such as...

    Authors: Andrea Bernini, Ottavia Spiga, Roberto Consonni, Ivana Arosio, Paola Fusi, Simone Cirri, Annamaria Guagliardi and Neri Niccolai

    Citation: BMC Structural Biology 2011 11:44

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  34. Content type: Research article

    Multiple acyl-coenzyme A dehydrogenase deficiency (MADD) is an autosomal recessive disease caused by the defects in the mitochondrial electron transfer system and the metabolism of fatty acids. Recently, mutat...

    Authors: Tze-Kiong Er, Chih-Chieh Chen, Yen-Yi Liu, Hui-Chiu Chang, Yin-Hsiu Chien, Jan-Gowth Chang, Jenn-Kang Hwang and Yuh-Jyh Jong

    Citation: BMC Structural Biology 2011 11:43

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  35. Content type: Research article

    Psychrophiles, cold-adapted organisms, have adapted to live at low temperatures by using a variety of mechanisms. Their enzymes are active at cold temperatures by being structurally more flexible than mesophil...

    Authors: Diana I Paredes, Kyle Watters, Derek J Pitman, Christopher Bystroff and Jonathan S Dordick

    Citation: BMC Structural Biology 2011 11:42

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  36. Content type: Research article

    Ydj1 and Sis1 are structurally and functionally distinct Hsp40 proteins of the yeast cytosol. Sis1 is an essential gene whereas the ydj1 gene is essential for growth at elevated temperatures and cannot complement...

    Authors: Julio C Silva, Julio C Borges, Douglas M Cyr, Carlos HI Ramos and Iris L Torriani

    Citation: BMC Structural Biology 2011 11:40

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  37. Content type: Research article

    Ribose-5-phosphate isomerase is an enzyme that catalyzes the interconversion of ribose-5-phosphate and ribulose-5-phosphate. This family of enzymes naturally occurs in two distinct classes, RpiA and RpiB, whic...

    Authors: Thomas E Edwards, Ariel B Abramov, Eric R Smith, Ruth O Baydo, Jess T Leonard, David J Leibly, Kaitlin B Thompkins, Matthew C Clifton, Anna S Gardberg, Bart L Staker, Wesley C Van Voorhis, Peter J Myler and Lance J Stewart

    Citation: BMC Structural Biology 2011 11:39

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  38. Content type: Research article

    Protein residue-residue contact prediction is important for protein model generation and model evaluation. Here we develop a conformation ensemble approach to improve residue-residue contact prediction. We col...

    Authors: Jesse Eickholt, Zheng Wang and Jianlin Cheng

    Citation: BMC Structural Biology 2011 11:38

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  39. Content type: Research article

    Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the first proteins localized to foci of DNA damage. Upon activation by encountering nicked DNA, the PARP-1 mediated trans-poly(ADP-ribosyl)ation of DNA binding ...

    Authors: Paul A Loeffler, Matthew J Cuneo, Geoffrey A Mueller, Eugene F DeRose, Scott A Gabel and Robert E London

    Citation: BMC Structural Biology 2011 11:37

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  40. Content type: Research article

    Ice nucleation proteins (INPs) allow water to freeze at high subzero temperatures. Due to their large size (>120 kDa), membrane association, and tendency to aggregate, an experimentally-determined tertiary str...

    Authors: Christopher P Garnham, Robert L Campbell, Virginia K Walker and Peter L Davies

    Citation: BMC Structural Biology 2011 11:36

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2017 Journal Metrics

  • Citation Impact
    1.308 - 2-year Impact Factor
    1.609 - 5-year Impact Factor
    0.643 - Source Normalized Impact per Paper (SNIP)
    1.024 - SCImago Journal Rank (SJR)


    Social Media Impact
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