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Page 8 of 12

  1. The structure, function and reaction mechanism of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) have been extensively studied. Based on these studies, three anion binding sites have been identified, one 'Ps...

    Authors: William J Cook, Olga Senkovich and Debasish Chattopadhyay

    Citation: BMC Structural Biology 2009 9:9

    Content type: Research article

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  2. The genome of a wide variety of prokaryotes contains the luxS gene homologue, which encodes for the protein S-ribosylhomocysteinelyase (LuxS). This protein is responsible for the production of the quorum sensing ...

    Authors: Moitrayee Bhattacharyya and Saraswathi Vishveshwara

    Citation: BMC Structural Biology 2009 9:8

    Content type: Research article

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  3. Imatinib represents the first in a class of drugs targeted against chronic myelogenous leukemia to enter the clinic, showing excellent efficacy and specificity for Abl, Kit, and PDGFR kinases. Recent screens c...

    Authors: Jonathan A Winger, Oliver Hantschel, Giulio Superti-Furga and John Kuriyan

    Citation: BMC Structural Biology 2009 9:7

    Content type: Research article

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  4. It is well known the strong relationship between protein structure and flexibility, on one hand, and biological protein function, on the other hand. Technically, protein flexibility exploration is an essential...

    Authors: Javier A Velázquez-Muriel, Manuel Rueda, Isabel Cuesta, Alberto Pascual-Montano, Modesto Orozco and José-María Carazo

    Citation: BMC Structural Biology 2009 9:6

    Content type: Research article

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  5. Prediction of protein structures from their sequences is still one of the open grand challenges of computational biology. Some approaches to protein structure prediction, especially ab initio ones, rely to some e...

    Authors: Ian Walsh, Davide Baù, Alberto JM Martin, Catherine Mooney, Alessandro Vullo and Gianluca Pollastri

    Citation: BMC Structural Biology 2009 9:5

    Content type: Research article

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  6. P-glycoprotein belongs to the family of ATP-binding cassette proteins which hydrolyze ATP to catalyse the translocation of their substrates through membranes. This protein extrudes a large range of components ...

    Authors: Jean-Paul Becker, Grégoire Depret, Françoise Van Bambeke, Paul M Tulkens and Martine Prévost

    Citation: BMC Structural Biology 2009 9:3

    Content type: Research article

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  7. Pyrococcus furiosus Hjm (Pfu Hjm) is a structure-specific DNA helicase that was originally identified by in vitro screening for Holliday junction migration activity. It belongs to helicase superfamily 2, and sha...

    Authors: Takuji Oyama, Hayato Oka, Kouta Mayanagi, Tsuyoshi Shirai, Kyoko Matoba, Ryosuke Fujikane, Yoshizumi Ishino and Kosuke Morikawa

    Citation: BMC Structural Biology 2009 9:2

    Content type: Research article

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  8. Mesothelin is a 40 kDa protein present on the surface of normal mesothelial cells and overexpressed in many human tumours, including mesothelioma and ovarian and pancreatic adenocarcinoma. It forms a strong an...

    Authors: Bangalore K Sathyanarayana, Yoonsoo Hahn, Manish S Patankar, Ira Pastan and Byungkook Lee

    Citation: BMC Structural Biology 2009 9:1

    Content type: Research article

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  9. Disulphide bridges are well known to play key roles in stability, folding and functions of proteins. Introduction or deletion of disulphides by site-directed mutagenesis have produced varying effects on stabil...

    Authors: Ratna R Thangudu, Malini Manoharan, N Srinivasan, Frédéric Cadet, R Sowdhamini and Bernard Offmann

    Citation: BMC Structural Biology 2008 8:55

    Content type: Research article

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  10. Present in various species, the knottins (also referred to as inhibitor cystine knots) constitute a group of extremely stable miniproteins with a plethora of biological activities. Owing to their small size an...

    Authors: Annie Heitz, Olga Avrutina, Dung Le-Nguyen, Ulf Diederichsen, Jean-François Hernandez, Jérôme Gracy, Harald Kolmar and Laurent Chiche

    Citation: BMC Structural Biology 2008 8:54

    Content type: Research article

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  11. For over 30 years potentials of mean force have been used to evaluate the relative energy of protein structures. The most commonly used potentials define the energy of residue-residue interactions and are deri...

    Authors: Dan M Bolser, Ioannis Filippis, Henning Stehr, Jose Duarte and Michael Lappe

    Citation: BMC Structural Biology 2008 8:53

    Content type: Research article

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  12. During the last years, methods for remote homology detection have grown more and more sensitive and reliable. Automatic structure prediction servers relying on these methods can generate useful 3D models even ...

    Authors: Vatsal Agarwal, Michael Remmert, Andreas Biegert and Johannes Söding

    Citation: BMC Structural Biology 2008 8:51

    Content type: Software

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  13. Catalytic domains of Type II restriction endonucleases (REases) belong to a few unrelated three-dimensional folds. While the PD-(D/E)XK fold is most common among these enzymes, crystal structures have been als...

    Authors: Katarzyna H Kaminska, Mikihiko Kawai, Michal Boniecki, Ichizo Kobayashi and Janusz M Bujnicki

    Citation: BMC Structural Biology 2008 8:48

    Content type: Research article

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  14. Leucine-rich repeats (LRRs) are present in more than 6000 proteins. They are found in organisms ranging from viruses to eukaryotes and play an important role in protein-ligand interactions. To date, more than ...

    Authors: Tiandi Wei, Jing Gong, Ferdinand Jamitzky, Wolfgang M Heckl, Robert W Stark and Shaila C Rössle

    Citation: BMC Structural Biology 2008 8:47

    Content type: Database

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  15. Eluted natural peptides from major histocompatibility molecules show patterns of conserved residues. Crystallographic structures show that the bound peptide in class II major histocompatibility complex adopts ...

    Authors: Christian S Parry

    Citation: BMC Structural Biology 2008 8:44

    Content type: Research article

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  16. Efficient communication between distant sites within a protein is essential for cooperative biological response. Although often associated with large allosteric movements, more subtle changes in protein dynami...

    Authors: Tom Lenaerts, Jesper Ferkinghoff-Borg, Francois Stricher, Luis Serrano, Joost WH Schymkowitz and Frederic Rousseau

    Citation: BMC Structural Biology 2008 8:43

    Content type: Research article

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  17. Soluble guanylate cyclases generate cyclic GMP when bound to nitric oxide, thereby linking nitric oxide levels to the control of processes such as vascular homeostasis and neurotransmission. The guanylate cycl...

    Authors: Jonathan A Winger, Emily R Derbyshire, Meindert H Lamers, Michael A Marletta and John Kuriyan

    Citation: BMC Structural Biology 2008 8:42

    Content type: Research article

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  18. An important element in homology modeling is the use of rotamers to parameterize the sidechain conformation. Despite the many libraries of sidechain rotamers that have been developed, a number of rotamers have...

    Authors: Bosco K Ho and David A Agard

    Citation: BMC Structural Biology 2008 8:41

    Content type: Research article

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  19. Prediction of function of proteins on the basis of structure and vice versa is a partially solved problem, largely in the domain of biophysics and biochemistry. This underlies the need of computational and bio...

    Authors: Kshitiz Gupta, Vivek Sehgal and Andre Levchenko

    Citation: BMC Structural Biology 2008 8:40

    Content type: Research article

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  20. The transcription factor NF-kappaB is a very interesting target molecule for the design on anti-tumor, anti-inflammatory and pro-apoptotic drugs. However, the application of the widely-used molecular docking c...

    Authors: Laura Piccagli, Enrica Fabbri, Monica Borgatti, Valentino Bezzerri, Irene Mancini, Elena Nicolis, Maria C Dechecchi, Ilaria Lampronti, Giulio Cabrini and Roberto Gambari

    Citation: BMC Structural Biology 2008 8:38

    Content type: Research article

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  21. Many studies have examined rules governing two aspects of protein structures: short segments and proteins' structural domains. Nevertheless, the organization and nature of the conformational space of segments ...

    Authors: Kazuyoshi Ikeda, Takatsugu Hirokawa, Junichi Higo and Kentaro Tomii

    Citation: BMC Structural Biology 2008 8:37

    Content type: Research article

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  22. There are considerable differences between bacterial and mammalian glycans. In contrast to most eukaryotic carbohydrates, bacterial glycans are often composed of repeating units with diverse functions ranging ...

    Authors: Stephan Herget, Philip V Toukach, René Ranzinger, William E Hull, Yuriy A Knirel and Claus-Wilhelm von der Lieth

    Citation: BMC Structural Biology 2008 8:35

    Content type: Research article

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  23. In search of new antifungal targets of potential interest for pharmaceutical companies, we initiated a comparative genomics study to identify the most promising protein-coding genes in fungal genomes. One crit...

    Authors: Sébastien Santini, Vincent Monchois, Nicolas Mouz, Cécile Sigoillot, Tristan Rousselle, Jean-Michel Claverie and Chantal Abergel

    Citation: BMC Structural Biology 2008 8:33

    Content type: Research article

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  24. Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The funct...

    Authors: Laure Gabison, Thierry Prangé, Nathalie Colloc'h, Mohamed El Hajji, Bertrand Castro and Mohamed Chiadmi

    Citation: BMC Structural Biology 2008 8:32

    Content type: Research article

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  25. Although multiple templates are frequently used in comparative modeling, the effect of inclusion of additional template(s) on model accuracy (when compared to that of corresponding single-template based models...

    Authors: Suvobrata Chakravarty, Sucheta Godbole, Bing Zhang, Seth Berger and Roberto Sanchez

    Citation: BMC Structural Biology 2008 8:31

    Content type: Research article

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  26. The Ambiguous Restraints for Iterative Assignment (ARIA) approach is widely used for NMR structure determination. It is based on simultaneously calculating structures and assigning NOE through an iterative pro...

    Authors: Benjamin Bardiaux, Aymeric Bernard, Wolfgang Rieping, Michael Habeck, Thérèse E Malliavin and Michael Nilges

    Citation: BMC Structural Biology 2008 8:30

    Content type: Software

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  27. Distantly related proteins adopt and retain similar structural scaffolds despite length variations that could be as much as two-fold in some protein superfamilies. In this paper, we describe an analysis of ind...

    Authors: Sankaran Sandhya, Barah Pankaj, Madabosse Kande Govind, Bernard Offmann, Narayanaswamy Srinivasan and Ramanathan Sowdhamini

    Citation: BMC Structural Biology 2008 8:28

    Content type: Research article

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  28. The structural stability of peptides in solution strongly affects their binding affinities and specificities. Thus, in peptide biotechnology, an increase in the structural stability is often desirable. The pre...

    Authors: Karin Noy, Nir Kalisman and Chen Keasar

    Citation: BMC Structural Biology 2008 8:27

    Content type: Methodology article

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  29. Ubiquitin (E3) ligases interact with specific ubiquitin conjugating (E2) enzymes to ubiquitinate particular substrate proteins. As the combination of E2 and E3 dictates the type and biological consequence of u...

    Authors: Zhen Xu, Ekta Kohli, Karl I Devlin, Michael Bold, Jay C Nix and Saurav Misra

    Citation: BMC Structural Biology 2008 8:26

    Content type: Research article

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  30. Allosteric coupling, which can be defined as propagation of a perturbation at one region of the protein molecule (such as ligand binding) to distant sites in the same molecule, constitutes the most general mec...

    Authors: Kemal Sayar, Özlem Uğur, Tong Liu, Vincent J Hilser and Ongun Onaran

    Citation: BMC Structural Biology 2008 8:23

    Content type: Research article

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  31. DNA polymerase beta (pol beta), the error-prone DNA polymerase of single-stranded DNA break repair as well as base excision repair pathways, is overexpressed in several tumors and takes part in chemotherapeuti...

    Authors: Corinne Hazan, François Boudsocq, Virginie Gervais, Olivier Saurel, Marion Ciais, Christophe Cazaux, Jerzy Czaplicki and Alain Milon

    Citation: BMC Structural Biology 2008 8:22

    Content type: Research article

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  32. PSAIA (Protein Structure and Interaction Analyzer) was developed to compute geometric parameters for large sets of protein structures in order to predict and investigate protein-protein interaction sites.

    Authors: Josip Mihel, Mile Šikić, Sanja Tomić, Branko Jeren and Kristian Vlahoviček

    Citation: BMC Structural Biology 2008 8:21

    Content type: Software

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  33. Comparison of experimentally determined mesophilic and thermophilic homologous protein structures is an important tool for understanding the mechanisms that contribute to thermal stability. Of particular inter...

    Authors: Matthew J Cuneo, Yaji Tian, Malin Allert and Homme W Hellinga

    Citation: BMC Structural Biology 2008 8:20

    Content type: Research article

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  34. Phosphorylation is a central feature in many biological processes. Structural analyses have identified the importance of charge-charge interactions, for example mediating phosphorylation-driven allosteric chan...

    Authors: James Kitchen, Rebecca E Saunders and Jim Warwicker

    Citation: BMC Structural Biology 2008 8:19

    Content type: Research article

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  35. Legionella pneumphila is the causative agent of Legionnaires' disease. A major virulence factor of the pathogen is the homodimeric surface protein Mip. It shows peptidyl-prolyl cis/trans isomerase activty and is ...

    Authors: Andreas Ceymann, Martin Horstmann, Philipp Ehses, Kristian Schweimer, Anne-Katrin Paschke, Michael Steinert and Cornelius Faber

    Citation: BMC Structural Biology 2008 8:17

    Content type: Research article

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2017 Journal Metrics

  • Citation Impact
    1.308 - 2-year Impact Factor
    1.609 - 5-year Impact Factor
    0.643 - Source Normalized Impact per Paper (SNIP)
    1.024 - SCImago Journal Rank (SJR)

    Usage 
    191,858 downloads


    Social Media Impact
    17 mentions

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