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  1. Database

    REFOLDdb: a new and sustainable gateway to experimental protocols for protein refolding

    More than 7000 papers related to “protein refolding” have been published to date, with approximately 300 reports each year during the last decade. Whilst some of these papers provide experimental protocols for...

    Hisashi Mizutani, Hideaki Sugawara, Ashley M. Buckle, Takeshi Sangawa, Ken-ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura and Kei Yura

    BMC Structural Biology 2017 17:4

    Published on: 24 April 2017

  2. Research article

    Prokaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteins

    The post-translational modification pathway referred to as pupylation marks proteins for proteasomal degradation in Mycobacterium tuberculosis and other actinobacteria by covalently attaching the small protein Pu...

    Jonas Barandun, Fred F. Damberger, Cyrille L. Delley, Juerg Laederach, Frédéric H. T. Allain and Eilika Weber-Ban

    BMC Structural Biology 2017 17:1

    Published on: 1 February 2017

  3. Methodology article

    Controlled dehydration improves the diffraction quality of two RNA crystals

    Post-crystallization dehydration methods, applying either vapor diffusion or humidity control devices, have been widely used to improve the diffraction quality of protein crystals. Despite the fact that RNA cr...

    HaJeung Park, Tuan Tran, Jun Hyuck Lee, Hyun Park and Matthew D. Disney

    BMC Structural Biology 2016 16:19

    Published on: 3 November 2016

  4. Methodology Article

    Combined small angle X-ray solution scattering with atomic force microscopy for characterizing radiation damage on biological macromolecules

    Synchrotron radiation facilities are pillars of modern structural biology. Small-Angle X-ray scattering performed at synchrotron sources is often used to characterize the shape of biological macromolecules. A ...

    Luca Costa, Alexander Andriatis, Martha Brennich, Jean-Marie Teulon, Shu-wen W. Chen, Jean-Luc Pellequer and Adam Round

    BMC Structural Biology 2016 16:18

    Published on: 27 October 2016

  5. Research article

    The C-terminal domain of TPX2 is made of alpha-helical tandem repeats

    TPX2 (Targeting Protein for Xklp2) is essential for spindle assembly, activation of the mitotic kinase Aurora A and for triggering microtubule nucleation. Homologs of TPX2 in Chordata and plants were previousl...

    Luis Sanchez-Pulido, Laurent Perez, Steffen Kuhn, Isabelle Vernos and Miguel A. Andrade-Navarro

    BMC Structural Biology 2016 16:17

    Published on: 26 October 2016

  6. Research

    Endocrine disruption: In silico perspectives of interactions of di-(2-ethylhexyl)phthalate and its five major metabolites with progesterone receptor

    Di-(2-ethylhexyl)phthalate (DEHP) is a common endocrine disrupting compound (EDC) present in the environment as a result of industrial activity and leaching from polyvinyl products. DEHP is used as a plasticiz...

    Ishfaq A. Sheikh, Muhammad Abu-Elmagd, Rola F. Turki, Ghazi A. Damanhouri, Mohd A. Beg and Mohammed Al-Qahtani

    BMC Structural Biology 2016 16(Suppl 1):16

    Published on: 30 September 2016

    This article is part of a Supplement: Volume 16 Supplement 1

  7. Research

    Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study

    Currently, alternate plasticizers are used to replace phthalate plasticizers in children’s toys, medical equipments and food packaging, due to the adverse effects of phthalate compounds on human health and law...

    Ishfaq A. Sheikh, Muhammad Yasir, Muhammad Abu-Elmagd, Tanveer A. Dar, Adel M. Abuzenadah, Ghazi A. Damanhouri, Mohammed Al-Qahtani and Mohd A. Beg

    BMC Structural Biology 2016 16(Suppl 1):15

    Published on: 30 September 2016

    This article is part of a Supplement: Volume 16 Supplement 1

  8. Research article

    Conservation of the C-type lectin fold for accommodating massive sequence variation in archaeal diversity-generating retroelements

    Diversity-generating retroelements (DGRs) provide organisms with a unique means for adaptation to a dynamic environment through massive protein sequence variation. The potential scope of this variation exceeds...

    Sumit Handa, Blair G. Paul, Jeffery F. Miller, David L. Valentine and Partho Ghosh

    BMC Structural Biology 2016 16:13

    Published on: 31 August 2016

  9. Research article

    3D QSAR, pharmacophore and molecular docking studies of known inhibitors and designing of novel inhibitors for M18 aspartyl aminopeptidase of Plasmodium falciparum

    The Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) is only aspartyl aminopeptidase which is found in the genome of P. falciparum and is essential for its survival. The PfM18AAP enzyme performs vario...

    Madhulata Kumari, Subhash Chandra, Neeraj Tiwari and Naidu Subbarao

    BMC Structural Biology 2016 16:12

    Published on: 17 August 2016

  10. Research article

    Comprehensive analysis of the Co-structures of dipeptidyl peptidase IV and its inhibitor

    We comprehensively analyzed X-ray cocrystal structures of dipeptidyl peptidase IV (DPP-4) and its inhibitor to clarify whether DPP-4 alters its general or partial structure according to the inhibitor used and ...

    Hiroyuki Nojima, Kazuhiko Kanou, Genki Terashi, Mayuko Takeda-Shitaka, Gaku Inoue, Koichiro Atsuda, Chihiro Itoh, Chie Iguchi and Hajime Matsubara

    BMC Structural Biology 2016 16:11

    Published on: 5 August 2016

  11. Research article

    Comparison of human and mouse E-selectin binding to Sialyl-Lewisx

    During inflammation, leukocytes are captured by the selectin family of adhesion receptors lining blood vessels to facilitate exit from the bloodstream. E-selectin is upregulated on stimulated endothelial cells...

    Anne D. Rocheleau, Thong M. Cao, Tait Takitani and Michael R. King

    BMC Structural Biology 2016 16:10

    Published on: 2 July 2016

  12. Research article

    Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

    The nuclear hormone receptor RORγ regulates transcriptional genes involved in the production of the pro-inflammatory interleukin IL-17 which has been linked to autoimmune diseases such as rheumatoid arthritis,...

    Douglas J. Marcotte, YuTing Liu, Kevin Little, John H. Jones, Noel A. Powell, Craig P. Wildes, Laura F. Silvian and Jayanth V. Chodaparambil

    BMC Structural Biology 2016 16:7

    Published on: 1 June 2016

  13. Research article

    Crystal structure of human S100A8 in complex with zinc and calcium

    S100 proteins are a large family of calcium binding proteins present only in vertebrates. They function intra- and extracellularly both as regulators of homeostatic processes and as potent effectors during inf...

    Haili Lin, Gregers Rom Andersen and Laure Yatime

    BMC Structural Biology 2016 16:8

    Published on: 1 June 2016

  14. Research article

    Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system

    The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through t...

    Jonathan M. Wagner, Sum Chan, Timothy J. Evans, Sara Kahng, Jennifer Kim, Mark A. Arbing, David Eisenberg and Konstantin V. Korotkov

    BMC Structural Biology 2016 16:5

    Published on: 27 February 2016

  15. Software

    Structuprint: a scalable and extensible tool for two-dimensional representation of protein surfaces

    The term ‘molecular cartography’ encompasses a family of computational methods for two-dimensional transformation of protein structures and analysis of their physicochemical properties. The underlying algorith...

    Dimitrios Georgios Kontopoulos, Dimitrios Vlachakis, Georgia Tsiliki and Sofia Kossida

    BMC Structural Biology 2016 16:4

    Published on: 24 February 2016

    The Publisher's Erratum to this article has been published in BMC Structural Biology 2016 16:6

  16. Research Article

    Crystal structure and functional implications of the tandem-type universal stress protein UspE from Escherichia coli

    The universal stress proteins (USP) family member UspE is a tandem-type USP that consists of two Usp domains. The UspE expression levels of the Escherichia coli (E. coli) become elevated in response to oxidative ...

    Yongbin Xu, Jianyun Guo, Xiaoling Jin, Jin-Sik Kim, Ying Ji, Shengdi Fan, Nam-Chul Ha and Chun-Shan Quan

    BMC Structural Biology 2016 16:3

    Published on: 11 February 2016

  17. Research article

    A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

    Multimeric naphthoquinones are redox-active compounds that exhibit antineoplastic, antiprotozoal, and antiviral activities. Due to their multimodal effect on perturbation of cellular oxidative state, these com...

    Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

    BMC Structural Biology 2016 16:1

    Published on: 28 January 2016

  18. Research article

    The crystal structure of the Hazara virus nucleocapsid protein

    Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fat...

    Rebecca Surtees, Antonio Ariza, Emma K. Punch, Chi H. Trinh, Stuart D. Dowall, Roger Hewson, Julian A. Hiscox, John N. Barr and Thomas A. Edwards

    BMC Structural Biology 2015 15:24

    Published on: 29 December 2015

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