Figure 4

Conservation of proline-rich motif in E glycoprotein. Shown here is the multiple sequence alignment of E glycoprotein across different members of Flaviviridae family generated using the same method as mentioned above and the proline-rich motif is marked with a rectangle. (*) at the bottom of the column indicates complete conservation of the residue while (:) indicates conserved substitution at that position. The "PWLP" motif in Dengue 2 is shown in bold.