Figure 4From: Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shufflingHomology model of clone A10 showing the residues correspondent to the point mutations. Interactions of (A) threonine 30 (magenta) and (B) glutamine 97 (orange). Interacting residues are labeled and shown as spheres. It is likely that the mutations would significantly destabilize the hydrophobic core leading to a conformation different to that shown in the figure.Back to article page