Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery

Table 3 Pairs of conserved distant pocket clusters, allosteric sites prediction.

Protein families for which we found a pair of structurally conserved pocket clusters at least 8 Å appart of each other. We used 50% and 75% as the structural conservation thresholds for each pocket cluster in each pair combined as shown in the first column with the sequence conservation threshold. *At least one of the pocket clusters was found to have at least 50% or 75% of its pockets significantly conserved at the sequence level. These results cover 1,128 protein families for which we had at least 5 representative structures.

ISSN: 1472-6807