Table 4 Highly over-represented and highly under-represented residue quadruplets at the vertices of tessellated thermostable proteins and the factors by which they differ with respect to mesophiles.

over-represented

under-represented

over-represented

under-represented

quad

factor

quad

factor

quad

factor

quad

factor

EEEE

7.473

PQRT

0.303

EEER

6.008

AIQS

0.380

EEEK

7.332

GGNQ

0.302

ELWW

5.520

DLQS

0.378

EEER

7.048

FLLQ

0.301

RRRV

5.222

KLST

0.377

MRRR

6.490

AQVY

0.301

AEER

5.106

ILNQ

0.373

EEKR

5.654

AAAN

0.299

EEPR

5.087

ENQS

0.370

IRRR

5.605

AAEQ

0.298

EERR

4.801

KKLS

0.370

EEEF

5.597

DSTT

0.296

AERR

4.538

KNQR

0.368

EEKK

5.282

ADDT

0.296

RRRY

4.508

FKQS

0.368

EEEV

4.936

AENQ

0.296

EEEE

4.508

LNQS

0.367

EEIK

4.889

NSTT

0.295

ERRR

4.458

EFNS

0.366

EIKK

4.881

ALPQ

0.292

IRRR

4.186

DILQ

0.365

EEIV

4.346

ADQR

0.292

EEGP

4.177

LMSY

0.364

EIKR

4.332

ANRT

0.292

EEGR

4.113

KLNS

0.362

EKRR

4.256

DNQV

0.292

ERRV

4.104

DDQS

0.361

IKRR

4.228

FGLQ

0.291

EGPR

4.092

LNSS

0.361

EEKV

4.225

AQST

0.291

EERW

4.015

EHIK

0.360

EEIR

4.169

ANTY

0.290

GPRR

3.963

KKST

0.358

EEEN

4.107

INSY

0.290

EEPP

3.951

GKSS

0.356

EEEY

4.092

DNQT

0.289

EERV

3.904

CGLL

0.354

KRRR

4.085

ANQV

0.289

AELR

3.792

LNQT

0.353